Viability Test of α-Mangostin against Oral Squamous Cell Carcinoma

Introduction: Oral Squamous Cell Carcinoma (OSCC) represents approximately 96% of the entire oral cancers. Epithelial-mesenchymal transition (EMT) is a factor contributing to poor prognosis associated with OSCC. α-mangostin one xanthones which show anti-cancer activities against some types cancers and can suppress EMT-induced invasion by increasing E-cadherin expression. This study aimed identify viability α-Mangostin reduce viable cells HOC313. Methods: The role induce HOC313 cell culture at various concentrations conducted on two groups: control group using only line intervention comprising added concentrations. In this present study, were treated after reaching confluency level 80% in 5x103 cells/well. used had six concentrations: 1.25 µM, 2.5 3.75 5 6.25 7.5 µM. Results: Concentration significant effect viability, p-value obtained was 0.023 (p < 0.05). Mann-Whitney test also performed differences between all treatment mg/ml value p = 0.02 1.25, 2.5, 3.75, 5, 6.25, µM unable Conclusion: Low possibly result biphasic leads increase line. Therefore, high might effectively inhibit cancer growth, migration, invasion.